Download GTU B.Pharma 2020 Summer 5th Sem BP501TT Medicinal Chemistry Ii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Summer 5th Sem BP501TT Medicinal Chemistry Ii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER? 5 ? EXAMINATION ? SUMMER -2020
Subject Code:BP501TT
Date: 26-10-2020
Subject Name: Medicinal Chemistry II
Time: 2:30 PM TO 5:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Enlist various histamine receptors. Discuss neurochemistry of histamine.
06

(b) Give the synthesis of Promethazine hydrochloride and diphenhydramine
05
hydrochloride.

(c) Write a note on Nitroglycerin as a Vasodilator.
05



Q.2 (a) Classify Diuretics with one structure in each class. Write mechanism of action,
06
uses and side effect of Acetazolamide.

(b) Write informative note on Anti-hypertensive agents and give the synthesis of
05
Methyldopate hydrochloride.

(c) Write a note on Gastric Proton pump inhibitors.
05



Q.3 (a) Classify Antiarrhythmic agents with one structure in each class. Write synthesis 06
of Disopyramide phosphate.

(b) Write short notes on heparin as anticoagulant and give the synthesis of
05
Warfarin.

(c) Give the synthesis the following: (Any two)
05
(i) Isosorbide dinitrite (ii) Chlorthiazide (iii) Furosemide.



Q.4 (a) Explain in detail the nomenclature and stereochemistry of steroidal compounds. 06

(b) Write a note on Anti-hyperlipidemic agents.
05

(c) Write informative note on Sex hormones.
05



Q.5 (a) Give the synthesis and uses of the following: (Any two)
06
(i) Tobutamide (ii) Benzocaine (iii) Dibucaine.

(b) Write a note on Antithyroid agents.
05

(c) Write a note on the natural products used as antineoplastic agents.
05



Q. 6 (a) Define and classify Antidiabetic agents. Give the synthesis of Procaine.
06

(b) Classify anti neoplastic alkylating agents with relevant examples.
05

(c) Write a note on Oral contraceptives.
05



Q.7 (a) Discuss the SAR of Local anesthetics.
06

(b) Write a note on Drugs used in Congestive Heart Failure.
05

(c) Write a brief note on H2-antagonists.
05
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