Download GTU B.Pharma 2019 Winter 5th Sem 2250004 Pharmaceutical Chemistry ? VII (Medicinal Chemistry I) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Winter 5th Sem 2250004 Pharmaceutical Chemistry ? VII (Medicinal Chemistry I) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 5 EXAMINATION ? WINTER -2019
Subject Code: 2250004 Date: 22-11-2019
Subject Name: Pharmaceutical Chemistry ? VII (Medicinal Chemistry - I)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80

Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1
(a) Explain effect of ionization and partition coefficient on biological activity of
06
drug molecule.

(b) Define diagnostic agent. Write a note on Radiological Contrast Media.
05

(c)
Define medicinal chemistry. Write a note on history of medicinal chemistry.
05



Q.2
(a) Define asthma. Describe antiasthmatic agents in detail.
06

(b) Explain bioisosterism in detail with examples.
05

(c)
Give synthesis, uses and IUPAC name of Ranitidine and Cetrizine.
05



Q.3
(a) Write note on: (1) Complexation (2) Hydrogen bonding
06

(b) Write detail note on proton pump inhibitors.
05

(c)
Define autocoid. Explain biosynthesis of eicosanoids.
05



Q.4
(a) Write synthesis of (1) Dicyclomine (2) Salbutamol (3) Omeprazole
06

(b) Describe SAR of -phenylethanolamine of sympathomimetic agents.
05

(c)
Define neuromuscular blocker. Explain SAR of muscarinic antagonist.
05



Q.5
(a) Explain following terms with examples:
06
(1) Expectorant
(2) Antidiarrheal agent
(3) Mucolytic

(b) Define nasal decongestant. Write note on antitussive agents.
05

(c)
Write detail note on ganglion blockers.
05



Q. 6
(a) Explain following terms with examples:
06
(1) Prokinetic (2) Antiemetic
(3) Antispasmodic

(b) Define and classify antacid and laxative.
05

(c)
Define and classify sympatholytic agent.
05



Q.7
(a) Give synthesis of followings:
06
(1) Chlorpheniramine (2) Promethazine (3) Atenolol

(b) What are eicosanoids? Differentiate H1 and H2 antagonist.
05

(c)
Answer the followings: (1) Chemistry of histamine
05
(2) Drug action mediated by eicosanoids
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