Download GTU B.Pharma 2018 Winter 3rd Sem 2230004 Pharmaceutical Chemistry Iv (Organic Chemistry I) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 3rd Sem 2230004 Pharmaceutical Chemistry Iv (Organic Chemistry I) Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 3- EXAMINATION ?WINTER - 2018

Subject Code: 2230004
Date: 12/12/2018
Subject Name: Pharmaceutical Chemistry-IV (Organic Chemistry - I)
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Write a note on determination of molecular weight of volatile substances.
06

(b) Discuss bonding and antibonding orbitals in details.
05

(c) Define carbocation. Discuss the structure and reactions of carbocations
05



Q.2 (a) Explain the reactions involving free radical as intermediate.
06

(b) State and explain : Saytzeff's rule, Antimarcovnikov addition
05

(c) Give the preparations and reactions of carbenes.
05



Q.3 (a) Give structural formula of the following compounds.
06
1) 2,3- dimethylpentane
2) 2,3-dimethyl-3-hexene
3) 2,2,6,6,7- Pentametyl octane
4) 4-methyl heptane
5) 3-ethyl -2,4-dimethyl pentane
6) 3-methyl hexane

(b) Write a note on Diels Alder reactions.
05

(c) Define hybridization? Explain SP3 hybridization with examples.
05



Q.4 (a) Correct if necessary and justify the following statements.
06
1) Cyloheptatrienylcation is aromatic according to Huckle's rule.
2) Dehydration of tertiary alcohol is faster than primary alcohol.
3)Alcohols are having higher boiling point than ether.
4) Benzene undergoes electrophilic substitution reaction.

(b) Differentiate between E2 and E1 mechanism of elimination with example
05

(c) Explain the principle of Dumas method and Kjeldahl's method in detail.
05



Q.5 (a) Give importance of Grignard reagent in various reactions.
06

(b) Write detail short notes on Huckel Rule for aromaticity.
05

(c) Write a note on hydrogen bonding.
05



Q. 6 (a) Write a note on Molecular orbital theory
06

(b) Give the preparation of benzene and anthracene.
05

(c) Describe the importance of resonance and hyperconjugation in stability and
05
reactivity of molecules.



Q.7 (a) Write short notes on Haworth synthesis of naphthalene in details.
06

(b) Explain the mechanism of halogenation for alkane.
05

(c) Discuss detail mechanisms of aldol condensation
05
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