Download GTU B.Pharma 2018 Winter 7th Sem 270003 Pharmaceutical Chemistry Ix (Medicinal Chemistry) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 7th Sem 270003 Pharmaceutical Chemistry Ix (Medicinal Chemistry) Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 7- EXAMINATION ?WINTER - 2018

Subject Code:270003
Date: 19/11/2018
Subject Name: Pharmaceutical Chemistry-IX (Medicinal Chemistry)
Time:10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) What are steroids? Give the structural classification of steroids.
06

(b) What are antifungal agents? How do they act? Sketch important steps for
05
synthesis of Ketoconazole.

(c) Classify anti-neoplastic agents and sketch important steps for synthesis of
05
Thiotepa.



Q.2 (a) Give IUPAC name and synthesis of (i) Fluorouracil and
06
(ii) Cyclophosphamide.

(b) Write the main points elucidating the SAR of Quinolines.
05

(c) Sketch the structures of Nystatin and Amphotericin B. Mention its usage.
05



Q.3 (a) Explain the degradation of Penicillin and write a short note on penicillinase-
06
resistant Penicillins.

(b) Draw chemical structures of iodinated compounds of thyroid glands.
05

(c) What are anabolic agents? Give SAR of testosterone.
05



Q.4 (a) What are Cephalosporins ? How do they differ from penicillins? Give SAR of
06
Cephalosporins.

(b) Justify the name "Tetracyclines". Elucidate its SAR.
05

(c) Write a short note on Rifamycin antibiotics.
05



Q.5 (a) Give life cycle of malarial parasite. Classify antimalarials with examples. Give
06
synthesis of Primaquine.

(b) Sketch the important steps involved in synthesis of Isoniazid and Ethambutol.
05

(c) Write a note on immunomoduators OR Antithyroid drugs.
05



Q. 6 (a) Classify Penicillins with examples on the basis of mechanism of action. Why
06
Penicillin is not active against penicillinase secreting microorganisms?

(b) Explain the mechanism of action of Co-trimoxazole. Write synthesis of
05
Trimethoprim and Sulfamethoxazole.

(c) Write the mechanism of action, metabolism, SAR and uses of Streptomycin.
05



Q.7 (a) What for are the neuraminidase inhibitors used? Mention its history and
06
development.

(b) Give IUPAC name and chemical synthesis of Chloramphenicol.
05

(c) What are Quinolones? Write structure activity relationship of Quinolones.
05
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