Download GTU B.Pharma 2018 Summer 1st Sem 818804 Pharmaceutical Organic Chemistry Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 1st Sem 818804 Pharmaceutical Organic Chemistry Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
Pharm D ? 1st Year ? EXAMINATION ? SUMMER - 2018
Subject Code: 818804
Date: 25/05/2018
Subject Name: Pharmaceutical Organic Chemistry
Time: 10:30 AM TO 1:30 PM
Total Marks: 70
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Classify Intramolecular Forces and Explain Bond dissociation Energy.
06

(b) Explain Following Terms
04
1. Heterolysis
2. Homolysis
3. Dipole-Dipole interaction
4.Polarity of bond

(c) Explain the reactivity and stability of free radical.
04



Q.2 (a) Discuss the mechanism and stereochemistry of SN1 AND SN2 reaction.
06

(b) Write a note on Carbocations with mechanism.
04

(c) Write a note on: Methods of preparation of cycloalkanes.
04



Q.3 (a) Explain the influence of activating and deactivating groups on the electrophillic 06
substitution of benzene.

(b) Explain oxidation-reduction reaction with examples.
04

(c) Give chemical structure and IUPAC name of following
04
2,2,4-Trimethylpentane, 1-methoxy-2-propanol,2-Nitrophenol ,Vinyl bromide



Q.4 (a) Give the preparation, test of purity, assay and medicinal use of
06
1. chlorbutol
2. Sodium lauryl sulphate.

(b) Differentiate E1 and E2 reaction.
04

(c) Explain the halohydrin formation.
04



Q.5 (a) Explain the following:
06
1.aldol condensation
2.Sandmeyer's reaction

(b) Explain the cycloaddition reaction.
04

(c) Explain the resonance and hyper-conjugation.
04



Q. 6 (a) Comment on the following
06
1. Meta nitro benzoic acid is more acidic than Para nitro benzoic Acid
2. Pyridine is aromatic
3. All Lowrie-Bronsted acids and bases can be Lewis acids and bases
but all Lewis acids and bases cannot be Lowrie-Bronsted acids and bases

(b) Write detail note on Nucleophilic substitution bimolecular.
04

(c) Explain Isomerism in organic compound
04



Q.7 (a) Explain the Perkin condensation and Kolbe reaction.
06

(b) Write free radical halogenations reaction of alkenes.
04

(c) Write a note on Markownikov's rule in detail.
04
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