Download GTU B.Pharma 2018 Summer 5th Sem 2250004 Pharmaceutical Chemistry Vii (Medicinal Chemistry I) Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 5th Sem 2250004 Pharmaceutical Chemistry Vii (Medicinal Chemistry I) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER?5 ? EXAMINATION ? SUMMER -2018
Subject Code: 2250004 Date: 21/05/2018
Subject Name: Pharmaceutical Chemistry - VII (Medicinal Chemistry - I)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Classify the antiasthamatic agents with chemical structures.
06

(b) What is autocoids? Write the chemistry, biosynthesis and metabolism of
05
histamine.

(c) Define neuromuscular blockers. Classify them with only names. Write the
05
therapeutic uses of them.



Q.2 (a) Describe optical and geometric isomerism of drugs. How do they affect the
06
drug's biological activity?

(b) Write the synthesis of i) any one H1-antihistamine containing phenothiazine
05
nucleus and ii) any one H1-antihistamine containing piperazine ring.

(c) Write a short note on indirectly acting sympathomimetics.
05



Q.3 (a) Define expectorants and mucolytics. Give two examples of expectorants and
06
two examples of mucolytics with chemical structures.

(b) Classify the muscarinic agonists with chemical structures.
05

(c) Write the synthesis of i) any one H+/K+-ATPase inhibitor and ii) any one -
05
blocker.



Q.4 (a) Define medicinal chemistry. Discuss the history of it.
06

(b) Write the synthesis of neostigmine and salbutamol.
05

(c) Discuss the development of H2-antihistamines. Write the therapeutic uses of
05
H2-antihistamines.



Q.5 (a) Write the neurochemistry of acetylcholine.
06

(b) Classify the antiemetics with chemical structures.
05

(c) Explain the SAR of parasympatholytics.
05



Q. 6 (a) Differentiate antacids and antisecretory agents. Write the mechanism of action
06
and examples with structures of proton pump inhibitors.

(b) Write a note on prokinetics.
05

(c) What is the measure of drug's lipophilicity? How does it affect the drug's
05
biological activity?



Q.7 (a) What is eicosanoids? Describe the biosynthesis of prostaglandins.
06

(b) Discuss various metabolic routes for norepinephrine.
05

(c) Write a short note on analeptics.
05
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