Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 8th Sem 280001 Dosage Form Design Ii Previous Question Paper
Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER?8 ? EXAMINATION ? SUMMER -2018
Subject Code: 280001 Date: 28/4/2018
Subject Name: Dosage form Design II
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
(a) Explain various biological factors to be considered in the design of
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sustained release dosage forms.
(b) Write a note on Bio erodible controlled drug delivery systems.
05
(c) Enlist various physicochemical factors to be considered in the design 05
of sustained release dosage forms. Discuss the effect of porosity and
tortuosity on release rate of sustained release formulations.
Q.2
(a) Discuss evaluation of release characteristics for the final dosage form 06
with respect to oral controlled release formulations.
(b) Explain non erodible and erodible ocular control release system.
05
(c) Write a note on burst effect with respect to controlled release
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diffusional systems.
Q.3
(a) Explain in detail about approaches for colon targeted drug delivery
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system.
(b) Write a note on evaluation of Transdermal drug delivery system.
05
(c) Explain in brief preparation of microspheres.
05
Q.4
(a) Discuss the formulation of parenteral emulsions and suspensions.
06
(b) Explain various types of osmotic pressure controlled systems with
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suitable diagram.
(c) Write a note on various classes of matrix tablets with respect to
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modified drug release dosage forms.
Q.5
(a) Draw typical plasma concentration time profile curve. Explain
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Pharmacokinetic and Pharmacodynamics parameters in brief.
(b) Give advantages and disadvantages of compartment modeling.
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(c) A drug has an elimination half life of 8 h and follows first order
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kinetics. If a single dose 200mg is given to an adult male patient (68
kg) by i.v. bolus injection, calculate the percent of the dose lost in
24h.
Q. 6
(a) Define clinical pharmacokinetics. Explain methods for the
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calculation of creatinine clearance from serum creatinine
concentration.
(b) Define drug interaction. Discuss interactions that involve a change in 05
drug absorption from GIT with suitable examples.
(c) Explain dosage adjustment in patients with renal and hepatic failure.
05
Q.7
(a) Explain how one can detect nonlinear pharmacokinetics? Explain 06
Michaelis Menten equation for capacity limited process.
(b) Describe One- compartment open model kinetic after iv bolus
05
administration.
(c) Write merits of non- compartmental analysis. Explain AUC &
05
AUMC plots
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This post was last modified on 05 March 2021