Download Pharm D 4th Year 2014 April 383823 Biopharmaceutics And Pharmacokinetics Question Paper

Download Pharm-D (Doctor of Pharmacy) 4th Year (Fourth Year) 2014 April 383823 Biopharmaceutics And Pharmacokinetics Previous Question Paper

[LE 823] APRIL 2014 Sub. Code: 3823
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE)
DEGREE EXAMINATION
FOURTH YEAR
PAPER V ? BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code: 383823
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. Drug elimination.
2. A 70 kg patient is to be a given a drug by i.v. infusion.
The drug has a half life of 22 hours, apparent volume of distribution 15.7 litres
and desired steady state plasma concentration is 0.0002 mcg/ml.
Assuming one compartment kinetics calculate; time to reach 90% steady state
concentration, infusion rate to achieve desired steady state concentration, loading
dose to attain steady state rapidly and concentration of drug in plasma after 48 hours
from the start of infusion.
II. Write notes on: (10 x 3 = 30)
1. Enlist physiological barriers for distribution.
2. Statistical interpretation of bioequivalence data.
3. Endocytosis.
4. Tissue localization.
5. Plasma level time curve.
6. Advantages of Catenary model.
7. Lineweaver-Burke Plot.
8. Persistance factor and loss factor.
9. Approaches for dosage regimen.
10. Dissolution apparatus I.

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