PTU (Punjab Technical University) B.Pharmacy Eight Semester May 2019 Question Paper
Total No. of Pages : 02
Total No. of Questions : 10
B.Pharma (2011 to 2016) (Sem.?8)
PHARMACEUTICAL CHEMISTRY ? VIII
(MEDICINAL CHEMISTRY ? III)
Subject Code : BPHM-805
M.Code : 72300
Time : 3 Hrs. Max. Marks : 80
INSTRUCTIONS TO CANDIDATES :
1.
SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying T WO
marks each.
2.
SECTION-B contains FIVE questions carrying FIVE marks each and students
have to attempt any FOUR questions.
3.
SECTION-C contains FOUR questions carrying T EN marks each and students
have to attempt any T HREE questions.
SECTION-A
1.
I. Give structure, IUPAC name and one specific use of following drugs :
a. Isoniazid
b. Methicillin.
c. Proguanil
d. Ornidazole
e. Mebendazole
f. Fluconazole
g. Abacavir
h. Docetaxel
i. Temoxifen
j. Methimazole
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II.
Attempt the following :
a. What is biotransformation?
b. Draw structures of two drugs that undergoes sulphonation by glutathione-S-transferase?
c. What are meglitinides?
d. Draw structures of T4 and T3 thyroid hormones?
e. Draw the structures of two aminopyrimidine derivatives used in combination therapy
with sulphonamide.
SECTION-B
2.
Discuss SAR of 4-aminoquinolines for anti-malarial activity.
3.
What are anthelmintics? Give synthesis of Nicolsamide.
4.
Draw structures of imidazole derivatives used for treatment of fungal infection. Give
synthesis of any one of them.
5.
Give an account of antithyroid drugs.
6.
Give structures and mechanism of action of purine analogues used as antiviral agents.
SECTION-C
7.
Describe various types of reactions involved in phase I of drug metabolism citing suitable
example of each.
8.
a) Discuss the SAR of thyroid hormones.
b) Discuss structure of insulin.
9.
Classify antineoplastic drugs with two structural examples of each class. Give synthesis of
chlorambucil.
10. What are (-lactam antibiotics? Describe various classes of penicillins.
NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.
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This post was last modified on 05 November 2019