Download PTU M-Pharma 2019 May 1st Semester 74664 ADVANCED ORGANIC CHEMISTRY I Question Paper

Download PTU (Punjab Technical University) M-Pharma (Master of Pharmacy) 1st Semester 74664 ADVANCED ORGANIC CHEMISTRY I Last 10 Years 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011 and 2010 Previous Question Papers.

1 | M-74664 (S31)-1037

Roll No. Total No. of Pages : 02
Total No. of Questions : 06
M.Pharma(Pharmaceutical Chemistry) (2017 & Onwards) (Sem.?1)
ADVANCED ORGANIC CHEMISTRY-I
Subject Code : MPC-102T
M.Code : 74664
Time : 3 Hrs. Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
1. Attempt any FIVE questions out of SIX questions.
2. Each question carries FIFTEEN marks.

Q1. a. Explain the stability of Free radicals with suitable examples. 3
b. Write down the products of formations from the reaction of nitrene and alkene. 3
c. Describe the methods of generation of carbenes. 3
d. Write down two methods for generation of carbanion centre from carbonyl carbon. 3
e. Discuss the stereochemical aspect of El and E2 reactions. 3
Q2. Write down the reaction mechanism of the following reactions :
a. Baeyer-Villiger Oxidation 5
b. Shapiro Reaction 5
c. Suzuki Reaction 5
Q3. Write down the applications of following reagents with appropriate examples :
a. Wilkinson's Catalyst 5
b. DCC 5
c. Wittig Reagent 5
Q4. a. Enumerate the needs for doing protection with examples. 3
b. What are the various ways used for protection and deprotection of -OH-group? 5
c. What are various methods for determining reaction mechanism? Explain one of the
method. 7
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1 | M-74664 (S31)-1037

Roll No. Total No. of Pages : 02
Total No. of Questions : 06
M.Pharma(Pharmaceutical Chemistry) (2017 & Onwards) (Sem.?1)
ADVANCED ORGANIC CHEMISTRY-I
Subject Code : MPC-102T
M.Code : 74664
Time : 3 Hrs. Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
1. Attempt any FIVE questions out of SIX questions.
2. Each question carries FIFTEEN marks.

Q1. a. Explain the stability of Free radicals with suitable examples. 3
b. Write down the products of formations from the reaction of nitrene and alkene. 3
c. Describe the methods of generation of carbenes. 3
d. Write down two methods for generation of carbanion centre from carbonyl carbon. 3
e. Discuss the stereochemical aspect of El and E2 reactions. 3
Q2. Write down the reaction mechanism of the following reactions :
a. Baeyer-Villiger Oxidation 5
b. Shapiro Reaction 5
c. Suzuki Reaction 5
Q3. Write down the applications of following reagents with appropriate examples :
a. Wilkinson's Catalyst 5
b. DCC 5
c. Wittig Reagent 5
Q4. a. Enumerate the needs for doing protection with examples. 3
b. What are the various ways used for protection and deprotection of -OH-group? 5
c. What are various methods for determining reaction mechanism? Explain one of the
method. 7
2 | M-74664 (S31)-1037

Q5. a. Write down the synthetic equivalent's for following synthons : 4

b. Suggest suitable steps for following conversion. 4

c. Write down both the retrosynthetic analysis and forward synthesis of the following
compound. 7

Q6. a. Describe the Combes Quinoline synthesis. 5
b. Write down the synthesis of Alprazolam. 5
c. Discuss the Pinner Pyrimidine synthesis. 5










NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.
O
?-nitroanion, Alkyl anion, Aryl cation
O
R R
1
RCHO
HN
F C
3
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