Download SGBAU B-Pharma 2019 Summer 3rd Sem Sem III Pharmaceutical Organic Chemistry New Question Paper

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BP301T

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Pharmaceutical Organic Chemistry - II

Time : Three Hours Max. Marks : 75

Notes:

1. All questions are compulsory.
2. Assume suitable data wherever necessary.

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3. Diagrams and chemical equations should be given wherever necessary.
4. Discuss the reaction, mechanism wherever necessary.
5. Use of pen Blue/Black ink/refill only for writing the answer book.

1. Multiple Choice questions. (20 Marks)
1. The carbon atom in benzene ring are ------------
   1. SP3 hybridized

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   2. Sp hybridized
   3. sp2 hybridized
   4. none of these
2. Characteristics reactions of aromatic compounds are initiated by ----------
   1. Electrophiles

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   2. Nucleophiles
   3. Free radicals
   4. None of these
3. For reactions of ethylbenzene, the ethyl group is considered -----------
   1. Ortho director

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   2. Ortho-para director
   3. Meta director
   4. Ortho-meta director
4. Benzene reacts with conc. HNO3 to give nitrobenzene in presence of --------
   1. FeCl3

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   2. UV light
   3. conc. H2SO4
   4. AlCl3
5. The electrophile in nitration of benzene is --------
   1. NO3-

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   2. NO+
   3. HNO3+
   4. NO2-
6. The hexagonal ring structure of benzene was proposed by -----------
   1. Berzelius

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   2. Kekule
   3. Friedel craft
   4. Bayer
7. Which of the following reagent gives picric acid when reacts with phenol ------
   1. nitric acid

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   2. sulfuric acid
   3. formaldehyde
   4. hydrogen
8. Aniline reacts with nitrous acid at low temperature to give ---------
   1. anitrile

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   2. N-nitrosamine
   3. diazonium salt
   4. anitrite salt
9. Phenyl magnesium bromide when followed by hydrolysis gives to form ----—----
   1. Phenol

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   2. Benzoic acid
   3. Bromobenzene
   4. Acetophenone
10. Fats and oils are ----------
    1. diesters of glycerol

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    2. diesters of glycol
    3. monoesters of glycerol
    4. triesters of glycerol
11. Alkaline hydrolysis of fats and oils is called -------- -
    1. Fermentation

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    2. Rancidification
    3. Saponification
    4. Hydrogenation
12. which of the following cycloalkanes have highest ring strain ----------
    1. Cyclopropane

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    2. Cyclobutane
    3. Cyclopentane
    4. Cyclohexane
13. Enzyme responsible for hydrolysis of fat is ---------
    1. Reductase

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    2. Aconitase
    3. Lipase
    4. Kinase
14. The degree of unsaturation fat can be determined by means of its ----------
    1. Iodine number

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    2. Saponification number
    3. Acetyl number
    4. Ester number
15. For electrophilic substitution reaction, carboxyl group in aromatic acid is -------
    1. Ortho-directing

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    2. Para-directing
    3. Meta-directing
    4. both (a) and (c)
16. Acyl chlorides are made by reacting aromatic acids with ----------
    1. PCl3

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    2. PCl5
    3. SOCl2
    4. All of above
17. Hofmann’s degradation reaction is used for the synthesis of ------
    1. Secondary aromatic amine

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    2. Primary aromatic amine
    3. tertiary aromatic amine
    4. none of above
18. Sulphonation of Phenol at room temperature gives ---==---==--
    1. para-isomer

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    2. ortho-isomer
    3. meta-isomer
    4. both (a) and (b)
19. Which of the following is most acidic ----------
    1. benzyl alcohol

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    2. cyclohexanol
    3. phenol
    4. o-nitrophenol
20. An aromatic molecule will -==-avee--
    1. Cyclic and planar

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    2. have (4n +2) p electrons
    3. have p cloud above and below the plane of molecule
    4. all of above
2. Short answer questions (answer any two). (2 x 10 = 20 Marks)

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1. What are fats and Oils? How we can check their quality?
2. Explain characteristics reactions of benzene
3. Explain the chemistry of Naphthalene.
3. Short answer questions (answer any seven). (7 x 5 = 35 Marks)
1. What are phenols? How are they prepared?

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2. Write the various reactions of fats and oils.
3. Write a note on aryl diazonium salts.
4. Write the methods of preparation of benzoic acid.
5. What are cycloalkanes? Describe Baeyer’s strain theory.
6. Explain the effect of electron donating and withdrawing groups on electrophilic aromatic substitution reactions with example.

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7. Write a note on aromaticity of benzene.
8. Write the reactions of phenols.
9. Explain factors affecting acidity of aromatic carboxylic acids.

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