Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 June (Master of Pharmacy) 1st Year (First Year) 1st Year 9338 100 Marks Bio Pharmaceutics And Pharmacokinetics Revised Scheme 4 Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - JUNE-2019
Time: Three Hours
Max. Marks: 100 Marks
Bio-Pharmaceutics and Pharmacokinetics
(Revised Scheme 4)
Q.P. CODE: 9338
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary. Answer any ten questions.
LONG ESSAY (Answer any TEN)
10 X 10 = 100 Marks
1.
Enumerate the different methods of determining absorption. Discuss in detail in-vitro methods.
2.
Discuss in detail physico-chemical factors affecting the absorption of drugs.
3.
Explain volume of distribution. How volume of distribution is estimated? Give its significance.
4.
Define the terms relative and absolute and bioavailability. Explain different methods used to
determine AUC.
5.
Explain the pharmacokinetics of a drug given by extravascular route which follows one
compartment open model.
6.
How do you determine elimination rate constant using urinary excretion data?
7.
Explain the process of renal excretion of drugs.
8.
Discuss the causes of non-linearity in pharmacokinetics and write briefly the tests to determine
the same.
9.
Define drug dissolution and explain various theories of drug dissolution.
10.
What are the main factors that influence drug dosing in renal disease? Explain briefly the
different methods for adjusting drug dose in renal disease.
11.
Write a note on therapeutic drug monitoring.
12.
Explain about Biopharmaceutics classification system.
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