Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 June (Master of Pharmacy) 1st Year (First Year) 2nd Year 5170 Advanced Biopharmaceutics And Pharmacokinetics Previous Question Paper

Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Degree Examination - JUNE-2019
[Time: 3 Hours]
[Max. Marks: 75]
Advanced Biopharmaceutics and Pharmacokinetics
Q.P. CODE: 5170
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Explain the Pharmacokinetics of a drug given by IV bolus, which follows one compartment open
model.
2.
What is bioequivalence? Discuss in detail various bioequivalence study designs.
3.
Explain various Pharmaceutical factors affecting the drug absorption.
4.
Discuss in detail in-vitro, in-vivo correlation. Explain briefly dissolution profile comparisons.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Write a note on cytochrome P-450 based drug interactions.
6.
Write a note on applications of Pharmacokinetics in targeted drug delivery systems.
7.
Discuss various factors to be considered in design of a drug product.
8.
Discuss the pH partition theory of drug absorption.
9.
Describe various in-situ methods of studying drug absorption.
10.
Write Michale's Menten equation. Write how do you estimate Vmax and Km?
11.
Define bioavailability. Write a note on various methods of assessing bioavailability.
12.
Discuss the various official methods of drug dissolution.
13.
Write a note on Pharmacokinetics and Pharmacodynamics of proteins and peptides.
14.
Discuss Noyes Whitey's equation of drug dissolution process.
* * * * *

---

Document Outline

• ??
• ??
• ??

---