Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 January (Master of Pharmacy) 1st Year (First Year) 1st Year 5135 Pharmacological And Toxicological Screening Methods I Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Semester M. Pharm Degree Examination - JAN-2019
[Time: 3 Hours]
[Max. Marks: 75]
Pharmacological and Toxicological Screening Methods-I
Q.P. CODE: 5135
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Enumerate methods to evaluate antidepressant activity of an agent. Discuss one in-vitro and
one in-vivo method.
2.
What are the mechanisms by which antianxiety agents act? List the screening methods and
discuss any two methods.
3.
List out the various screening methods for antiulcer activity. Discuss one stress induced and
one chemically induced ulcer model.
4.
List the commonly used methods to screen an agent for antihypertensive agents. Discuss one
in-vitro and one in-vivo method.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Write a note on the pharmacological uses of rat as laboratory animal.
6.
Write a brief note on maintenance of laboratory animals.
7.
Explain two models for screening an agent for antiparkinsonian activity.
8.
Explain a model to evaluate central analgesic activity of an agent.
9.
Write a note on preclinical screening methods of antiemetic agents.
10.
Explain two preclinical models to evaluate antipyretic activity of an agent.
11.
Enumerate the models for screening of antianginal activity and explain the Langendorff
technique.
12.
List the methods to screen antidiabetic agents, explain any one model.
13.
Write a note on limitations of animal experimentation.
14.
Write a note on immunoassays.
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