Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2018 May (Master of Pharmacy) 2nd Year 5159 Computer Aided Drug Design II Previous Question Paper

Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Degree Examination - MAY-2018
[Time: 3 Hours]
[Max. Marks: 75]
Computer Aided Drug Design -II
Q.P. CODE: 5159
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Explain Hansch and Free Wilson method of analysis with a suitable example and
relationship between them.
2.
Discuss the approaches for 3D-QSAR analysis.
3.
Write the protocols to be followed in In silico virtual screening.
4.
Discuss the energy minimization methods in molecular modeling.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Describe the docking of agents on AchE.
6.
Explain the method of generation of 3D-structure of a protein.
7.
What is log P? How it is determined? Give its significance.
8.
Explain the docking of agents on DHFR enzyme.
9.
Explain pharmacopher mapping.
10.
Discuss homology modeling of a protein.
11.
Describe extra precision docking.
12.
Explain the electronic parameters to be considered in QSAR.
13.
Write a note on counter map analysis.
14.
Discuss the role of computer aided drug design in drug discovery.
* * * * *

---

Document Outline

• ??
• ??
• ??

---