Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2017 December (Master of Pharmacy) 1st Year 5119 Advanced Medicinal Chemistry Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Semester M. Pharm Degree Examination - DEC-2017
[Time: 3 Hours]
[Max. Marks: 75]
Advanced Medicinal Chemistry
Q.P. CODE: 5119
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Discuss the various stages involved in identification of a lead molecule. Explain the methods of
lead optimization and its objectives.
2.
What are antihypertensive agents? Classify with examples. Write the synthesis and MOA of
Propranalol.
3.
Discuss the modification of various functional groups in the design of prodrugs.
4.
Explain the rational design of non-covalently and covalently binding enzyme inhibitors with
examples.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Explain the different theories of drug-receptor interactions.
6.
Explain the different strategies to combat drug resistance in anticancer therapy.
7.
Write a note on design of stereo isomers and geometric isomers with respect to analog deign of
drugs.
8.
Classify anticonvulsant agents with examples. Write the MOA and synthesis of Phenobarbitone.
9.
Write a note on COX1 inhibitors. Write the synthesis of any one COX1 inhibitor.
10.
Classify antiviral agents with examples. Write the synthesis of zidovidine.
11.
Explain in detail enzyme inhibitors in basic research with examples.
12.
What are peptidomimetics? Explain its therapeutic importance.
13.
Outline the importance of high throughput screening with applications.
14.
Write a brief note on designing of peptidomimetics.
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