Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2016 November (Master of Pharmacy) 1st Year 9348 Medicinal Chemistry II Natural Products Revised Scheme 4 Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
First Year M. Pharm Degree Examination ? NOV 2016
Time: Three Hours

Max. Marks: 100 Marks
MEDICINAL CHEMISTRY-II (Natural Products)
(Revised Scheme 4)
Q.P. CODE: 9348
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two)
2 x 20 = 40 Marks
1.
a) Describe in detail the theoretical and practical aspects of microbial conversions.
b) Enumerate the different reactions possible by microbial conversions. (10+10)
2.
a) Describe the significance of structural features, mechanism of action and classification of
a) Cephalosporins b) Other lactam antibiotics.
b) Show how the structure of emetine has been arrived at. (10+10)
3
a) Describe the physiological role of sex hormones. Write their structures. Describe the
SAR and development of anabolic agents for treatment of infertility.
b) Classify adrenal cortex hormones; give their therapeutic role. Discuss the structural
modifications done to obtain useful medicinal agents. (12+8)
SHORT ESSAYS (Answer any FIVE)
5 x 10 = 50 Marks
4.
Depict the metabolism of Purines and Pyrimidines.
5.
Establish the structure of Morphine.
6.
Discuss the chemistry of vitamin B1 with suitable illustrations.
7.
Describe the chemistry and development of ?lactamase stable cephalosporins.
8.
Describe the chemistry of carotenoids and discuss the constitution of Vitamin A.
9.
Elucidate the structure of Reserpine.
SHORT NOTES
2 x 5 = 10 Marks
10.
Describe the chemistry and MOA of antiparasitic Purine and Pyrimidine related compounds.
11.
Discuss the biosynthesis and structure of Vitamin D.
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