Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2015 November (Master of Pharmacy) 1st Year 9338 Biopharmaceutics And Pharmacokinetics Revised Scheme 4 Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - NOVEMBER 2015
[Time: 3 Hours]
[Max. Marks: 100]
Biopharmaceutics and Pharmacokinetics
(Revised Scheme 4)
Q.P. CODE: 9338
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
Explain in detail about physicochemical properties of drug absorption.
2.
What is pharmacokinetic model? Explain one compartment open model in detail with i.v bolus
drug administration. Derive various pharmacokinetic parameters of the same.
3.
Explain multiple dosing with respect to i.v and oral route in detail.
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Determination of rate of absorption by Wagner-Nelson Method
5.
In vitro, in vivo correlation
6.
Explain various causes of non-linearity reaction. With the help of equation, estimate Km and
Vmax using Michaelis Mention equation.
7.
What are the various factors affecting rate of distribution?
8.
Physiological pharmacokinetic model
9.
Phase I reactions
SHORT NOTES
2 X 5 = 10 Marks
10.
MRT for various compartmental model
11.
Therapeutic drug monitoring
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