Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2014 November (Master of Pharmacy) 1st Year 9232 Advanced Pharmaceutical Chemistry Org. Paper II Revised Scheme 2 Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - Oct/Nov 2014
[Time: 3 Hours]
[Max. Marks: 100]
ADVANCED PHARMACEUTICAL CHEMISTRY (ORG.)
PAPER II
(Revised Scheme 2)
Q.P. CODE : 9232
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
1.
Write an account of formation, stability and reactions of enzyme catalysis in the manufacture of
drugs.
2.
a) Explain about various reactions, which involve nitrenes.
b) Give the mechanism with examples of Diel's Alder and Sommelet ? Hauser reactions.
3.
a) Discuss different solid-phase methods in combinatorial chemistry.
b) Discuss the various reactive intermediates produced in organic synthesis with one example
each.
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
4.
Explain about aromatic nucleophilic reactions.
5.
Give mechanisms of Wolff rearrangement and Cannizzaro reaction.
6.
Explain phase transfer catalysis in anhydride and ester hydrolysis reactions.
7.
Explain the applications of macro beads in New Solid Phase synthesis.
8.
Explain about the Aldol condensation and Cope's rearrangement by giving examples.
9.
Write about various applications of Pericyclic reactions.
SHORT NOTES
2 X 5 = 10 Marks
10.
Advantages of combinatorial chemistry
11.
Mechanism of Pinacol-Pinacolone rearrangement
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