Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2014 November (Master of Pharmacy) 1st Year 9353 Advanced Medicinal Chemistry Revised Scheme 4 Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
First Year M. Pharm Degree Examination ? Oct/Nov 2014
Time: Three Hours

Max. Marks: 100 Marks
ADVANCED MEDICINAL CHEMISTRY
(Revised Scheme 4)
Q.P. CODE: 9353
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two)
2 x 20 = 40 Marks
1.
a) What are Cholinergic agents? Discuss the cholinergic blocking agents in detail.
b) Show how the structure of atropine has been arrived at. (10+10)
2.
a) Write a note on drug metabolism involving oxidation and conjugation reactions. With
suitable examples.
b) Discuss the effect of the following physico chemical properties on drug action with
suitable examples. A) Partition coefficient B) Bioisosterism C) Protein Binding. (10+10)
3
Discuss in detail the process of CADD. Add a note on substituents constants useful for
QSAR analysis. (20)
SHORT ESSAYS (Answer any FIVE)
5 x 10 = 50 Marks
4.
Classify sedatives and hypnotics with suitable examples. Add a note on SAR of barbiturates
and outline the synthesis of Chlordiazepoxide and Phenobarbitol.
5.
Classify adrenergic blocking agents with suitable examples. Outline the synthesis of any
drugs under this class.
6.
Outline the metabolism of purines and pyrimidins.
7.
Prove the structure of ephedrine.
8.
Classify steroids and triterpenoids with relevant examples. Discuss the development of
antifertility agents.
9.
What are the various factors to be considered while designing a new drug? Explain in detail.
SHORT NOTES
2 x 5 = 10 Marks
10.
Classify anticonvulsants with suitable examples. Outline the synthesis of phenytoin sodium
and carbamazepine.
11.
Write the examples of sympathomimetic agents and mention their specific uses. Outline
the synthesis of naphazoline.
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