Date: 08-08-2024
0824E 207
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours

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Max Marks: 100
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.

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4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Structured Long Question (Any 1

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out of 2) (1x10 Marks = 10 marks)

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(10)
a) write about hormonal regulation
of blood glucose. Add a note on
Glycogen metabolism. (6+4=10)
b) Write about hemoglobin

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biosynthesis. Add a note on abnormal
hemoglobin's. (5+5=10)
2. Case based/Applied short notes
(Any 2 out of 3) (2x6 marks = 12
marks)

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(12)
a) A 30 year old male suffering from
malaria and was under anti-malarial
drugs. During treatment he developed
signs of anemia. Laboratory findings

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showed decreased Hemoglobin and
increased bilirubin levels. (1+3+2=6)
1. Name the enzyme deficient in this
pathway.

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2. Explain the biochemical basis for

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hyperbilirubinemia.
3. Name the pathway involved with its
significance.
b) A 20 year old girl was referred to
hospital with complaints of muscle

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cramps and progressive muscle
weakness. Symptoms were
aggravated with exercise, high fat diet
and fasting. (1+3+2=6)
1. What is the deficient molecule?

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2. Metabolic pathway involved and role
of deficient molecule.
3. What is the cause of muscle
weakness?
c) 55 year women had history of loss

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of appetite, nausea, vomiting and
Flue(viral) like symptoms since 7 days.
Her urine was dark in colour and

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noticed icterus over past two days.
Laboratory findings- Total Bilirubin=

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8.5 mg/dl. Direct Bilirubin = 4.6 mg/dl,
serum ALT = 1000 IU/L, Alkaline
phosphatase = 250 IU/L.: (1+5=6)
1, What is the diagnosis
2. Write any three differentiating point

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between Prehepatic, hepatic and
obstructive jaundice.
3. Write short notes (Any 3 out of 4)
(3x6 marks = 18 marks)
(18)

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a) Define oxidative Phosphorylation.
Explain chemiosmotic theory.
b) Galactose metabolism.
c) Liver function tests with their
significance.

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d) Phospholipids and their functions.
4. Answer only in 2-3 sentences (Any

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5 out of 6) (5x2 marks = 10 marks)
(10)
a) Enumerate four important

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Glycosaminoglycans with their
function.
b) Define glycolysis and
gluconeogenesis.
c) Enumerate types of

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immunoglobulins with their functions.
d) Inhibiters of Electron transport
chain.
e) Qualities of Good doctor.
f) Structural difference between starch

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and glycogen.
Section 2
5. Structured long question (Any 1
out of 2) (1x 10 marks = 10 marks)
(10)

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a) Define and classify Enzymes

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with suitable examples. Add a note on
Cardiac enzymes. (1+6+3=10)
b) Describe Beta oxidation of Fatty
acids (palmetic acid) with its

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energetics. (7+3=10)
6. Write short notes (Any 2 out of 3)
(2x6 marks = 12 marks)
(12)
a) Phase-ll reactions of detoxification

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(Conjugation) with examples.
b) Draw a well labeled diagram of cell
membrane and add a note on active
transport.
c) Hormonal regulation of blood PH.

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7. Write short notes (Any 3 out of 4)
(3x6 marks = 18 marks)
(18)
a) Role of hormones in water balance.
b) Role of Radio isotopes in diagnosis

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and prognosis of various diseases.

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c) Tumor markers. Examples with
clinical significance.
d) Basic principles of communication
(AETCOM) wh

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8. Answer only in 2-3 sentences (Any
5 out of 6) (5x2 marks = 10 marks)
(10)
a) Enumerate causes of metabolic
acidosis.

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b) Essential fatty acids with their
functions.
c) Define Chromatography with its
applications.
d) Ketosis

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e) Enumerate factors affecting enzyme
activity.
f) Coenzymes with their functions.

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Document Outline

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