Download MBBS TMU 1st Year 2019 MBS103 Biochemistry II Question Paper

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) TMU (Teerthanker Mahaveer University) First Year (1st Year) 2019 MBS103 Biochemistry II Previous Question Paper


MBBS I (First) Professional Examination 2018-19

Course Code: MBS103 Paper ID: 03219242

Biochemistry -II

Time: 2 Hours 40 Minutes

Max Marks: 40

Note: Attempt all questions. Draw proper diagrams to support

your answer.

Part `B'

1.

Discuss the process of transcription in eukaryotes with
reference to promoter and termination sequences. Explain
its activation by at least two important activators. (10)

2. a) What is the active form of vitamin D and how it is formed?

Explain the role of calcitriol in regulation of serum calcium
level. (5)

b)

Mention sources, daily requirement and biologically active
forms of folic acid. How is it involved in one-carbon
metabolism? Enlist folate antagonists and explain their
clinical significance. (5)

3.

Briefly describe the following: (2.5x4=10)

a)

Immunologic dysfunction in AIDS

b)

Renin ? Angiotensin Aldosterone system

c)

List the important tumor markers

d)

Protein misfolding and diseases related to it.


4.

Write short notes on the following: (2.5x4=10)

a) Role of cytochrome P450 in hydroxylation reactions
b) Renal function tests
c) DNA melting
d)

(PUFA) Poly Unsaturated Fatty Acids





MBBS I (First) Professional Examination 2018-19

Roll No.

Student's Name



Student's Signature

Invigilator's Signature



Course Code: MBS103



Paper ID: 03219242

Biochemistry - II

Part `A'



Time: 20 Minutes

Max Marks: 10

Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.
2. Please tick () correct one only. Cutting, overwriting or any other marking are not allowed.
3. For answering please use Ball- pen only.






d)

Mycoplasma

Q.1

The enzyme involved in replication of
prokaryotic DNA is mainly:

Q.9

Which step in translation require ATP:

a)

DNA polymerase I

a)

Activation of amino acids

b)

DNA polymerase III

b)

Initiation

c)

DNA polymerase beta

c)

Elongation

d)

Primase

d)

Termination



Q.2

The sequence CCA occurs at the 3'-end of :

Q.10 An accurate DNA replication requires all

a. rRNA

the following except:

b. mRNA

a)

DNA ligase

c. tRNA

b)

The

-

exonuclease activity

d.

snRNA

c)

A free

OH

d)

Topoisomerase activity

Q.3

Erythrocyte transketolase activity is



decreased in:

P.T.O.

a)

Pellagra

Q.11 The vitamin absent in plant source is:

b)

Beriberi

a)

Cobalamin

c)

Pernicious anemia

b)

Folic acid

d)

Megaloblastic anemia

c)

Thiamine

d)

Riboflavin

Q.4

Which one of the following is not a feature
of cellular DNA replication:



a)

Semi-conservative

Q.12 In humans' the Epstein Barr virus is

b)

Chain growth in

to

direction

associated with:

c)

Bidirectional

a)

Carcinoma

d)

Semi-discontinuous

b)

Naso-pharyngeal carcinoma

c)

Carcinoma pancreas

Q.5

Which one of the following is encoded by

d)

Hepato-biliary carcinoma

the genome:
a)

Beta-alanine

Q.13 Significant increase in alkaline posphatase

b)

Hydroxyproline

and conjugated bilirubin levels in blood are

c)

Selenocysteine

indicators of:

d)

Hydroxylysine

a)

Parenchymal liver disease

b)

Cholestatic liver disease

c)

Inflammatory liver disease

Q.6

Which of the following is not a component

d)

None of the above

of the cell's suite of damage repair and
prevention agents:

Q.14 The antigen specificity of a particular B

a)

Superoxide dismutase

cell:

b)

Glutathione

a)

is induced by interaction with

c)

Isoaspartyl methyltransferase

antigen

d) Catalase

b)

is determined only by the L-chain
sequences

Q.7

Which of the following vitamins provides

c)

is determined by H+L-chain

the cofactor for reduction reactions in fatty

variable region sequence

acid synthesis :

d)

Change after isotype switching

a)

Folate

b)

Niacin

c)

Riboflavin d)

Thiamin

Q.15 The complement activity is abolished if

serum is incubated for 30 min at:

Q.8

Which living organism has the smallest

a)

37 ?C

genome:

b)

54 ?C

a)

E. coli

c)

56 ?C

b)

Staphloccus

d)

72 ?C

c)

Salmonella

Q.16 Which among the following

immunoglobulins is the first to be
synthesized by neonats:
a)

IgA

b)

IgM

c)

IgD

d)

IgG

Q.17 Which of the following is the central

molecule and major opsonin of complement
pathway:
a)

Cl

b)

C2

c)

C3b

d)

C5

Q.18 Name the class of MHC which is

recognized by CD4 TH cell:
a)

MHC cannot recognize T cells

b)

MHC III

c)

MHC I

d)

MHC II

Q.19 Immunologic memory is provided by:

a)

B cells and T cells

b)

Macrophages

c)

NK cells



d)

Phagocytes

Q.20 Methylation of DNA is important in which

DNA repair pathway:
a)

Direct repair

b)

Recombinational repair

c)

Nucleotide excision repair

d)

Mismatch repair

This post was last modified on 17 February 2022