Download RTMNU B.Pharma 3rd Semester 2017 Summer Pharmaceutical Chemistry 3 (Organic) Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 3rd Semester 2017 Summer Pharmaceutical Chemistry 3 (Organic) Question Paper

Time :
NKT/KS/l 7/6553
B.Pharm. Semester?III (C.B.S.) Examination
PHARMACEUTICAL CHEMISTRY?III (Organic)
Paper?Z
Three Hours] [Maximum Marks : 80
Note :?(1) Question No. 1 is compulsory.
(2) Solve any four questions from remaining.
(3) Discuss the reaction, mechanism wherever necessary.
1. Solve any ?ve of the following :
(a)
(b)
(c)
(d)
(e)
(D
(g)
2. (a)
(b)
(b)
(b)
Justify giving examples, cyclopropane always undergo ring opening reactions.
What product would you expect when bromine dissolved in carbon tetrachloride reacts with
propene in the presence of water ? Write the mechanism for this reaction.
Write a note on hydration of propyne.
Among benzaldehyde and acetaldehyde, which will undergo Cannizzaro reaction and why ?
Write the laboratory tests used for identifying various classes of amines.
Write a note on 'oc-halogenation of aliphatic acids.
Discuss the reactivity of toluene and nitrobenzene mononitration. 4X5=20
Explain the nucleophilic aliphatic substitution reaction which is accompanied with complete
inversion of con?guration. 9
Give an elaborate account of E2 mechanism. 6
Explain the mechanism of nucleophilic addition to carbonyl compounds and write some
important reactions given by aldehydes and ketone. 8
State and explain the preparation and reactions of phenol. 7
Grignard reagent is one of the most versatile reagents in organic chemistry. Justify the
statement giving suitable examples. Depict the mechanism involved in the formation of this
reagent. 10
Write the mechanism of cumene hydroperoxide rearrangement. 5
NXO?12535 1 (Contd.)

5. How will you plan for the following synthesis from benzene (any ?ve) :
(a)
(b)
(C)
(d)
(e)
(D
6. (a)
(b)
p-toluidine
m-bromophenol
p?amino benzoic acid
diphenyl methane
picric acid
styrene ? 3X5=15
Explain Markonikov?s and Anti?markonikov's orientation giving examples and mechanism
involved. 9
Write a note on halogenation of alkane. 6
7. Write short notes on (any three) :
(a)
(b)
(C)
(d)
Hofmann degradation reaction
Aldo] condensation
Reimer?Tiemann reaction
Pyrolysis and cracking. 5X3=15
8. Give a detailed account of electrophic aromatic substitution reactions covering mechanism,
reactivity and orientation. 15
NXO?12535 2 NKT/KS/17/6553