Download University of Jaffna (University of Sri Lanka) MBBS (Bachelor of Medicine and Bachelor of Surgery) 2011 February Pathology Paper II Previous Question Paper
SECOND EXAMINATION FOR MEDICAL DEGREES PART II--FEBRUARY 2011
PATHOLOGY Paper II
Date: 22.02.2011.
Time: 03 hours
ANSWER ALL THE TEN QUESTIONS
Answer each QUESTION in separate answer book
1.
A patient is found to have a mid-diastolic murmur and is diagnosed as
having mitral stenosis. He has a past history of Rheumatic Fever.
List 2 other possible causes for mitral stenosis.
(20 Marks)
List 2 complications of mitral stenosis.
(20 Marks)
Describe the microscopic and macroscopic changes of the heart in
Acute Rheumatic Fever.
(50 Marks)
1.4.
List 2 other organs I tissues involved in Acute Rheumatic Fever.
(10 Marks)
2.
A 68 year old known Diabetic patient presented with chronic cough, loss of
weight and low grade fever. Chest X Ray revealed upper lobe shadows
with cavitation. A clinical diagnosis of pulmonary Tuberculosis was made.
2.1.
List 2 investigations that would help to confirm the diagnosis.
(20 Marks)
2.2.
Describe the pathological features of secondary (post primary)
pulmonary Tuberculosis.
(40 Marks)
2.3.
List 2 other pathological conditions of the lung that can cause
granulomatous inflammation.
(20 Marks)
2.4.
Enumerate the pathological sequalae of secondary pulmonary
Tuberculosis.
(20 Marks)
3.
40 year old female admitted with lump in the right breast of six months
duration.
3.1.
Mention 5 physical signs to suggest it's clinically malignant lesion.
(20 Marks)
3.2.
Explain the above physical signs on the basis of the pathology.
(60 Marks)
3.3.
What is the significance of receptor studies in breast carcinoma?
(20 Marks)
Page 1 of 3
4.
4.1.
What laboratory investigations help to diagnose obstructive
jaundice?
(30 Marks)
4.2.
Brief out the pathophysiological changes that occur in obstructive
jaundice.
(35 Marks)
4.3.
Enumerate the causes of cirrhosis of the liver and mention the
different macroscopic morphologicalappearances of the liver in each
of them.
(35 Marks)
5.
A 40 year old male presented with burning epigastric pain related to meals.
An endoscopy performed on him revealed an ulcer at gastric antrum. The
biopsy done on it revealed a chronic gastric ulcer with no evidence of
malignancy.
5.1.
Define Peptic Ulcer.
(10 Marks)
5.2.
Describe the macroscopic and microscopic appearances of peptic
ulcer in stomach (gastric ulcer).
(40 Marks)
53.
List 3 natural defenses in the stomach to protect it from gastric
acidity.
(15 Marks)
5.4.
Describe the pathological mechanism of Helicobacter pylori causing
peptic ulcer
(15 Marks)
5.5.
Mention 3 other aetiological agents for peptic ulcer disease
(10 Marks)
5.6.
Enumerate the complications of peptic ulcer.
(10 Marks)
6.
6.1.
Define Chronic Kidney Disease.
(20 Marks)
6.2.
List the common 5 causes of Chronic Kidney Disease.
(30 Marks)
6.3.
What are the consequences and complications of Chronic Kidney
Disease?
(50 Marks)
7.
A 40 year old female presented with excessive weight gain in spite of
decreased appetite. Clinical diagnosis of Hypothyroidism was made.
7.1.
List 2 investigations that would confirm the diagnosis.
( 10 Marks)
7.2.
Mention the changes that you would expect in the investigations you
mentioned in 7.1 inprimary and secondary hypothyroidism.
(20 Marks)
7.3.
List 5 causes of hypothyroidism.
(30 Marks)
7.4.
List the clinical manifestations of hypothyroidism in relation to:
7.4.1. Cardiovascular system
(20 Marks)
7.4.2. Central nervous system
(20 Marks)
Page 2 of 3
8.
8.1.
List 5 important differences between benign and malignant tumours.
(50 Marks)
8.2.
Describe the macroscopic and microscopic appearances of uterine
leionayorna.
(40 Marks)
8.3.
Mention the name for malignant counterpart of leiomyoma.
(10 Marks)
9.
A 68 year old man presented with lethargy and shortness of breath on
exertion. He mentioned about passing dark colour stools on and off for 6
months. His preliminary
investigations revealed;
Hb-5.001;
MCV- 60f1;
1\40-1-20pg:
WBC-7000/mm3
Platelets-520,000/mm3
9.1.
What is the most likely cause for his anaemia?
(10 Marks)
9.2.
List 2 other causes for microcytic anaemia.
(20 Marks)
9.3.
List 3 biochemical investigations that you would do to confirm your
diagnosis mentioned in 7.1 giving the expected findings
(30 Marks)
9.4.
Describe the morphology of the red cells expected in his blood film.
(30 Marks)
9.5.
What is the most likely cause for his thrombocytosis?
(10 Marks)
10. A 32 year old lady presented with loss of weight and fatigability of 6
months duration. On examination there was massive splenomegaly.
?
10.1. List 3 conditions that can give rise to massive splenomegaly.
(30 Marks)
10.2. Her investigations showed:
Hb-lOgicil
\NBC-- 480,000/m M3
a
Platelets-900,000/mm 3
Blood picture revealed marked leukocytosis with ful spectrum of myeloid series with
peaks in neutrophils and myelocytes. Eosinophilia and Basophilic were seen. Blasts
were less than 2 %.
What is the most likely diagnosis?
(20 marks)
?
10.3. Mention one investigation from the peripheral blood that would
Confirm the diagnosis.
(20 Marks)
10.4 Briefly explain her massive splenomegaly on the basis of pathology. (30 Marks)
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This post was last modified on 19 October 2021