Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2019 Winter 5th Sem New 2153601 Pharmaceutical Chemistry Previous Question Paper
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ? V (New) EXAMINATION ? WINTER 2019
Subject Code: 2153601 Date: 21/11/2019
Subject Name: Pharmaceutical Chemistry
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a)
What are Antithyroid drugs? Give two examples with structure
03
(b)
Suggest a commercial root for the synthesis of anticonvulsant drug
Phensuximide which is having a 5 membered Pyrrolidine dione ring.
04
(c)
Write the MOA & Synthesis of Oral anti-diabetic drug- Pioglitazone.
07
Q.2 (a)
Write any four guidelines for choosing a disconnection in organic synthesis
by synthon approach. Give suitable examples.
03
(b)
What are the classifications of Androgens? What are the therapeutic uses of
Androgens? Give two examples of Androgens with structure.
04
(c)
Name the Thyroid hormones and write their functions. Write the synthesis
of Thyroid drug-Levothyroxine.
07
OR
(c)
By disconnection approach, suggest a scheme for the synthesis of anti-
malarial drug Chloroquine having a quinoline structure.
07
Q.3 (a)
By disconnection approach, suggest a scheme for the synthesis of
Isoproterenol
03
(b)
Write the metabolism of Testosterone.
04
(c) By disconnection approach suggest a scheme for the synthesis of
Antifungal Econazole
07
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Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ? V (New) EXAMINATION ? WINTER 2019
Subject Code: 2153601 Date: 21/11/2019
Subject Name: Pharmaceutical Chemistry
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a)
What are Antithyroid drugs? Give two examples with structure
03
(b)
Suggest a commercial root for the synthesis of anticonvulsant drug
Phensuximide which is having a 5 membered Pyrrolidine dione ring.
04
(c)
Write the MOA & Synthesis of Oral anti-diabetic drug- Pioglitazone.
07
Q.2 (a)
Write any four guidelines for choosing a disconnection in organic synthesis
by synthon approach. Give suitable examples.
03
(b)
What are the classifications of Androgens? What are the therapeutic uses of
Androgens? Give two examples of Androgens with structure.
04
(c)
Name the Thyroid hormones and write their functions. Write the synthesis
of Thyroid drug-Levothyroxine.
07
OR
(c)
By disconnection approach, suggest a scheme for the synthesis of anti-
malarial drug Chloroquine having a quinoline structure.
07
Q.3 (a)
By disconnection approach, suggest a scheme for the synthesis of
Isoproterenol
03
(b)
Write the metabolism of Testosterone.
04
(c) By disconnection approach suggest a scheme for the synthesis of
Antifungal Econazole
07
2
OR
Q.3 (a)
Write any four guidelines for choosing a disconnection in organic synthesis
by synthon approach. Give suitable examples.
03
(b)
By disconnection approach arrive at the starting material for the organic
synthesis of the Cis isomer of anti-cancer drug Combretastatin A-4. Discuss
the strategies employed to get the Cis isomer
04
(c)
What are Hormonal Contraceptives? Describe the classifications of Oral
contraceptive with suitable examples.
07
Q.4 (a)
Write down the general names and structures of steroids having 18, 19, 21
and 27 carbons.
03
(b)
By disconnection approach arrive at a suitable scheme for the synthesis of
Propranolol
04
(c)
Write the SAR of Progesterones
07
OR
Q.4 (a)
Write the structures of following: (1). 5 ?, 19-nor-androst-3-one, (2).
11?,17?,21-trihydroxypregn-4-ene-3,20-dione.
03
(b)
Briefly describe Calcium Homeostasis
04
(c)
Write the synthesis of (1R,2S)(-)Ephedrine by disconnection approach.
Describe the separation of (1R,2S)(-) Ephedrine from the 4 isomeric
mixtures obtained from the chemical synthesis.
07
Q.5 (a)
Write the Mode of Action (MOA) & Structural Activity Relationship (SAR)
of Sulphonyl Urea class of oral hypoglycaemic drugs.
03
(b)
Write the metabolism of Oestrogens
04
(c)
Write the synthesis of third generation Cephalosporin drug-Cefotaxime
using 7-ACA
07
OR
Q.5 (a)
Write the classifications of hormones.
03
(b)
By synthon approach, suggest a scheme for the synthesis of H1-
Antihistamine-Meclizine
04
(c)
Describe the chemical degradation of Penicillin
07
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This post was last modified on 20 February 2020