Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Rajiv Gandhi University of Health Sciences 1025 Biochemistry Paper II 2022 March Previous Question Paper
QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase -- I (CBME) Degree Examination - 08-Mar-2022
Time: Three Hours
Max. Marks: 100 Marks
BIOCHEMISTRY -- PAPER II (RS-4)
Q.P. CODE: 1025
(QP contains three pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS
2 x 10 = 20 Marks
1.
A child of two years presented with convulsions. He was taking normal feeds, But his
mother observed mousy odour of child's urine. Urine ferric chloride test was positive.
Plasma phenylalanine was found to be elevated. He was diagnosed to have phenyl
Ketonuria
a) What is the biochemical defect in phenyl Ketonuria?
b) Describe the catabolism of phenylalanine
c) Give the biochemical reasons for mousy odour in this case
2.
Describe protein biosynthesis in prokaryotes. Mention three inhibitors of protein
biosynthesis
SHORT ESSAYS
8 x 5 =40 Marks
3. A 45 year old man presented with severe back pain and weakness. He had lost 7 kgs in last
three months. He complained of loss of appetite and fatigue. X-ray showed punched out
lesions. Urine is positive for Bence Jones protein
a) Name the disorder in above case
b) What are Bence Jones proteins?
c) What is the electrophoretic pattern that is observed in this case?
4.
A known case of diabetes and hypertension on irregular treatment presented with swelling
of both lower limbs and puffiness of face. He was diagnosed with chronic kidney disease
(CKD)
a) Mention two biochemical parameters altered in CKD.
b) Explain the test to assess glomerular function of Kidney.
5.
What is Porphyria? Write the types of porphyria. Mention enzyme defect and clinical features
of acute intermittent porphyria
6.
How are free radicals generated? Describe the free radical scavenging systems
7. List the hormones which function with cAMP as second messenger. Describe the mechanism
of action of steroid hormones
8.
Enumerate the reactions of purine salvage pathway. Name the disorders that is associated
with this pathway and write its clinical features
9.
What are restriction endonucleases? Give two examples. Explain their role in Recombinant
DNA technology
10. What Is polymerase chain reaction (PCR)? Explain the steps in PCR. Write two applications
of PCR
SHORT ANSWERS
11.
List out the assays done for evaluation of thyroid function. Enumerate the laboratory
findings in hyperthyroidism
12.
What is detoxification? Give two examples of detoxification by oxidative reaction
13.
What are reference intervals? List out two pre analytical variables
14.
What is Southern Blotting Technique? Mention its applications
15.
Name three nucleotides and write their biological importance
16.
What is innate and adaptive Immune response?
17.
Give three examples of tumour markers and write their clinical Importance
18. Write the serum and urinary biochemical findings in hemolytic Jaundice
19. What are oncogenes? What are the factors that activate oncogenes?
20. What are essential amino acids? Give examples
Multiple Choice Questions
10 x 1 = 10 Marks
21 i)
Heme is converted to bilirubin in
A. Mitochondria
B. Microsomes
C. Golgi apparatus
D. Plasma membrane
21 ii) Immunogobulin which crosses placenta is
A. IgG
B. IgA
C. IgM
D. IgD
21 iii) The amino acid which do not allow formation of alpha helix is
A. Glutamate
B. Proline
C. Tyros ine
D. Histidine
21 iv) Histones are rich in
A. Glutamic acid and aspartic acid
B. Glycine and serine
C. Methionine and cysteine
D. Arginine and Histidine
21 v)
Which of the following is a termination codon?
A. AAG
B. CAG
C. CAA
D. UAG
22 I) In which of the following phase of cell cycle DNA replication takes place
A. G1
B. G2
C. S
QP CODE : 1025
(z,
22 ii)
Which of the following antioxidant enzyme Is selenium dependent?
?
A . G l u t a t h i o n e p e r o x i d a s e
B . Glutathione reductase
C . N AD P H o x i d a s e
D . C a t a l a s e
22 iii) Which of the following compound used in the treatment of gout Is a competitive inhibitor
of xanthine oxidase?
A . P r o b e n i c i d
B . A l l o p u r i n o l
C . Colchicine
D . Ace ta mi n o p h e n
22 iv) Normal serum level of albumin is
A . 1 . 5 t o 2 . 5 g m / d i
B . 3 . 5 t o 5 g m / d i
C . 6 t o 7 . 5 g m / d l
D . 9 to I.1 g midi
22 v)
End product of catabolism of protein is?
A . U r e a
B . U r i c a c i d
C . C r e a t i n i n e
D . Orotic acid
This post was last modified on 22 May 2022