RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPERI
Time: 3 hours
Max Marks: 100

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Date: 25-01-2023
Instructions: INSTRUCTIONS: Attempt all questions
in both sections: (Use separate answer book for
each section)
Section 1

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1. Fill in the blanks: (6)
a. Lipoprotein responsible for reverse cholesterol
transport is _______________.
b. Secondary structure present in collagen protein
_______________.

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c. Low Km value indicates _______________ affinity
between enzyme and substrate.
d. Chemical name of calcitriol is _______________.
e. Nitric oxide is synthesized from _______________
amino acid.

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f. Type of bilirubin increased in obstructive jaundice
is _______________.
2. Choose the correct option in the following
multiple choice questions: (4)
a. Which type of inhibition Warfarin has on vitamin K

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dependent carboxylase?
a) Competitive
b) Non - competitive
c) Allosteric
d) Suicidal

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b. Polysaccharide does not give colour with iodine
test:
a) Starch
b) Dextrin
c) Cellulose

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d) Glycogen
c. Von - Gierke's disease is characterized by all
except:
a) Lactic acidosis
b) Hyperglycemia

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c) Hyper uricemia
d) Hyperlipidemia
d. Complex of electron transport chain not functions
as proton pump:
a) Complex I

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b) Complex II
c) Complex III
d) Complex IV
3. A 66 years age obese male had severe chest
pain in the morning after doing exercise. He

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describe pain as retrosternal and radiating to the
left arm. On investigation (15) serum troponin I was
raised. He had complaint of dyspnoca and
intermittent palpitations. Based on this history
answer:

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a. What is probable diagnosis?

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b. What other investigations are to be performed for
diagnosis?
c. What is the role of isoenzymes in diagnosis of this
case?

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d. What is flipped pattern?
e. What are various risk factors for this disease?
4. Write short notes on (Any five) (10)
a. Ferritin
b. Anion gap (A.482)

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c. Atherosclerosis. (A.317)
d. Uncouplers
e. Denaturation of proteins
f. Transaminases.
5. Explain briefly (Any three) (15)

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a. Chemiosmotic theory
b. Krebs Henseleit cycle.
c. Fate of Acetyl COA (A.253)
d. Functions of electrolytes.

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Section 2

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6. Discuss the reactions of cycle with its energetic.
Suggest role of vitamins in Krebs cycle. (20)
7. Explain Why (Any Five) (10)
a. Liver cannot utilize ketone bodies.
b. Insulin is given to diabetics by subcutaneous route

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c. Eating raw eggs causes biotin deficiency.
d. Vitamin C is not synthesized in starvation.
e. Ketoacidosis is observed in starvation.
f. Ammonia is toxic to brain. (A.336)
8. Explain briefly (Any Four ) (20)

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a. Products obtained from Glycine amino acid.
(A.344)
b. Biochemical functions and deficiency
manifestations of Vitamin A.
c. Diagnostic significance of enzyme

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d. Differential diagnosis of jaundice.
e. Gluconeogenesis.
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Document Outline

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