RUHS
First Year MBBS Examination
I MBBS BIOCHEMISTRY PAPER I
Time: 3 hours
Max Marks: 100

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Date: 27-01-2023
Instructions: INSTRUCTIONS: Attempt all questions in
both sections: (Use separate answer book for each
section)
Section 1

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1. Fill in the blank (6)
a. Most common type of phase-ll reactions in xenobiotics
metabolism is ________
b. Formula for calculation of eGFR in males is _________
c. Maternal immunoglobulin providing immunity to foetus

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is _________
d. Enzyme used for conversion of RNA into DNA is
_________
e. Protein helping in correct spatial arrangement of
nascent polypeptide chain _________

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f. Water soluble vitamin with antioxidant properties is
_________
2. Choose the correct option in the following multiple
choice questions: (4)
a. Which of the following has high calorific value:

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a. Glucose

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b. Palmitic acid
c. Albumin
d. Ethanol
b. All are true regarding genetic code except:

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a. Ambiguous
b. Degenerate
c. Non- overlapping
d. Universal
c. Enzyme playing role in prevention of aging:

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a. DNA polymerase
b. Topoisomerase
c. Deoxyribonuclease
d. Telomerase
d. Which of the following process make use of free radical

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effect:
a. Cell adhesion
b. Phagocytosis
c. Contact inhibition
d. Transcytosis

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3. A 30 year old woman presented to OPD with jaundice.
Her serum alkaline phosphatase levels found to be ten
times higher than reference range.
a. What is the probable diagnosis? (15)
b. What are the different liver enzymes used to diagnose

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the liver disease?
c. Which type of bilirubin is high in this patient?
d. What are the different markers used to assess the
synthetic functions of liver?
e. What are the urine and stool findings in this condition?

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4. Write short notes on: (10)

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a. Plasmid.
b. Properties of genetic code.
c. IgA
d. Useful effects of reactive oxygen species.

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e. Applications of RFLP.
5. Explain briefly (Any three): (15)
a. Western blotting.
b. Antioxidant vitamins.
c. Antibiotics inhibiting translation.

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d. Creatinine clearance better than urea clearance.
Section 2
6. Give an account of polymerase chain reaction with its
different steps. Write five applications of the technique in
medicine. (20)

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7. Explain Why: (10)
a. Deficiency of vitamin C causes bleeding gums.
b. Mitochondrial DNA is more prone to mutations.
c. High blood ammonia levels are toxic to body.
d. Pyrimidine catabolic products are non-hazardous.

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e. Post transcriptional modifications are required. (A.557)
8. Explain briefly (Any four): (20)
a. Restriction endonuclease.
b. Monoclonal antibodies.
c. Catalase.

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d. Basal metabolic rate.
e. Replication bubble.
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