Download RGUHS M.Pharm 2nd Year 2020 5170 Advanced Biopharmaceutics And Pharmacokinetics Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharm (Master of Pharmacy) 2nd Year (2nd Semester) 2020 5170 Advanced Biopharmaceutics And Pharmacokinetics Previous Question Paper

Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Degree Examination - 13-Jan-2020
Time: Three Hours
Max. Marks: 75 Marks
ADVANCED BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 5170
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Explain one compartmental open model with extra vascular route of administration along with
various pharmacokinetic parameters.
2.
Explain the various mechanisms of drug absorption.
3.
Describe the in vitro drug dissolution testing models. Explain their merits and limitations.
4.
Explain the causes of non linearity in pharmacokinetics of drugs. Add a note on estimation of
Vmax and Km.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Explain pH partition hypothesis and its limitations.
6.
Explain the protocol for bioequivalence studies.
7.
Discuss Pharmacokinetic drug interactions.
8.
Write the objectives of bioavailability studies. Enlist the methods for measurement of
bioavailability. Explain method using plasma concentration data.
9.
Define and classify compartment models. Discuss briefly the significance and limitation of
compartment modeling.
10. Write the applications of Pharmacokinetic in novel drug delivery systems.
11. Explain the influence of gastric emptying and intestinal transit time on absorption of drugs.
12. Explain in -vivo methods for determining absorption of drugs.
13. Discuss Pharmacokinetics and Pharmacodynamics of biotechnology drugs.
14. Explain biological as factors affecting drug absorption.
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