Download B.Pharm 3rd Year 2018 February 564262 Medicinal Chemistry I Question Paper

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B.PHARM. DEGREE EXAMINATION

THIRD YEAR

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PAPER II - MEDICINAL CHEMISTRY - I

Time: Three hours Maximum: 100 Marks

I. Elaborate on: (2x20=40)

1. Explain the following physiochemical parameters related to biological activity with example.
   1. Chelation
   2. Steric effect

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   3. Optical isomerism
   4. Surface activity
2. 1. Define Sedative and Hypnotics? Classify with example.
   2. Give detailed account of structure activity relationship of Sympathomimetics.

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   3. Outline the synthesis for: (i) Prochlorperazine Maleate ii) Ketamine HCL

II. Write notes on: (8x5=40)

1. Describe the metabolism of adrenergic neurotransmitters.
2. Relate the structural features of Acetylcholine; Carbachol, Bethanechol and Methacholine.

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3. Give four structures of Neuromuscular blockers.
4. Outline the synthesis of Naproxen and Ibuprofen.
5. Give the route of synthesis of Amiloride and Frusemide.
6. Draw any four structures of anti-histamines.
7. Give the synthesis and mechanism of action of Doxapram HCL.

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8. Classify anti-convulsants with at-least one structure for each class.

III. Short answers on: (10x2=20)

1. Draw the structure and medicinal uses of Meperidine HCI.
2. Define the term Eicosanoids.
3. Sketch the structure and medicinal uses of Morphine analogues.

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4. Write a note on Omeprazole and Lansoprazole.
5. Outline the structures of Mephenytoin and Trimethadione.
6. Explain about Prodrugs.
7. Draw two structures of Cholinergic blocking agents.
8. Define the term Local anaesthetics with two examples.

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9. Sketch two structures of anti-hypertensive.
10. Give two reactions of Phase-I Metabolism.

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