Download RTMNU B.Pharma 6th Semester 2017 Winter Pharmaceutics 6 Question Paper

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NRJ/KW/17/4285

B.Pharm. Sixth Semester Examination

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PHARMACEUTICS—VI (Physical Pharmacy)

Paper-1

Time : Three Hours] [Maximum Marks : 80

N.B. :— (1) Question No. 1 is compulsory.

(2) Solve any four questions from remaining.

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(3) Draw neat labelled diagram wherever necessary.

(4) Assume suitable data wherever necessary.

1. Solve any five of the following : 4×5=20
   1. Why addition of sodium oleate to phenol water system lowers the critical solution temperature ?
   2. Define glass transition temperature (Tg). Explain effect of cross linking on Tg of polymer.
   3. What is active and passive diffusion ? What is osmosis and ultrafiltration ?

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   4. Define solubility according to I.P.
   5. Define rate, order and molecularity of a reaction. What do you understand by pseudo-order reaction ?
   6. What are bulges and spurs in the hysteresis loop ?
   7. What are complexes ? Give one example.

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2. Derive an equation for solubility of non-ionic solids in liquids. 15
3. Explain steady state diffusion and derive Ficks First and Second law of diffusion. Add a note on measurement of diffusion coefficient. 15
4. What are Non-Newtonian systems ? Explain their types and comment briefly on thixotropy. 15
5. 1. What is the influence of pH on solubility of weak acids and weak bases ? 8
   2. Give applications of polymers in Drug delivery systems. 7

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6. 1. Write principle, working, disadvantages and modifications of Cup and Bob viscometer. 8
   2. Explain metal ion complexes. 7
7. 1. How the stoichiometric ratio and ability constant is determined by solubility and distribution method ? 8

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   2. How the half-life and shelf-life of drugs can be calculated ? 7

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